December 2022

The Hunt for Novel Therapeutics Through Antibody Engineering

2022-12-02T11:22:32-05:00December 2nd, 2022|Articles|

Written by Genya Gorshtein, MSc November 1, 2022 Contents Introduction Approaches for Engineering Antibody Therapeutics Driving Antibody Engineering with Next Generation Protein Sequencing and Proteomics Introduction Antibody engineering encompasses various development, production strategies, and modification techniques to improve the biological properties of monoclonal antibodies (mAbs) as therapeutic [...]

Cell Specific Protein Degradation with Antibody Conjugated PROTACs

2022-12-02T10:23:52-05:00December 2nd, 2022|Articles|

Written by Genya Gorshtein, MSc November 25, 2022 Contents Introduction General PROTAC Structure and Function Antibody-Conjugated PROTACs Developing AbPROTACs with De Novo Antibody Sequencing and Proteomics Introduction Small-molecule drug development is aimed at inhibiting disease-promoting protein function through occupancy-driven protein inhibition. A major caveat of this therapeutic [...]

October 2022

Selecting Specific Monoclonal Antibodies by SPR – Alpaca Antibody Showdown

2022-11-30T19:36:55-05:00October 30th, 2022|Webinars|

In this SPR webinar, you will learn: How SPR works and its unique advantages for kinetic analysis of antibody-antigen interactions Applications of SPR in antibody discovery Functionality of SPR in antibody characterization Abstract Due to their ability to bind biomolecules specifically and tightly, antibodies are highly [...]

Characterizing Biomolecular Interactions with Surface Plasmon Resonance

2022-10-21T10:16:43-04:00October 21st, 2022|Articles|

Written by Vanessa Yoon Calvelo, PhD September 15, 2022 Contents Analyzing Biomolecular Interactions SPR Applications for Biomolecular Interactions SPR – A golden standard for biomolecular interaction analysis Analyzing Biomolecular Interactions Biological processes are driven by molecules that interact through specific molecular contacts, often to form a stable [...]

September 2022

Characterizing Fragile Protein Complexes

2022-10-26T14:01:04-04:00September 14th, 2022|Webinars|

Webinar Highlights You will learn: Introduction to the structure and function of the tuberous sclerosis protein complex (pTSC) A novel strategy for isolating and purifying protein complexes from native sources using recombinantly produced Fabs How Next Generation Protein Sequencing (NGPS) works Applications of NGPS to aid design and engineering of recombinant antibody [...]

August 2022

Surface Plasmon Resonance Spectroscopy

2022-08-17T19:50:31-04:00August 16th, 2022|Articles|

Written by Vanessa Yoon Calvelo, PhD August 11, 2022 Contents What is Surface Plasmon Resonance Spectroscopy? How Does SPR Work? SPR Experimental Workflow SPR Sensorgram SPR Advantages Antibody-Antigen Binding Analysis with SPR SPR Antibody-Antigen Interaction Analysis at Rapid Novor What is Surface Plasmon Resonance Spectroscopy? Surface plasmon [...]

July 2022

May 2022

April 2022

Identifying CDRs by Antibody Sequencing

2022-11-17T13:59:26-05:00April 1st, 2022|Articles|

Written by Yuning Wang, PhD March 15, 2022 Contents What are CDRs? Antibody CDRs De Novo Protein Sequencing as a Tool for Identifying CDRs Sequences Applying De Novo Protein Sequencing to Identify CDRs Sequences Annotation Schemes for Identifying CDRs by Sequence Rapid Novor can Help with Identifying CDRs by Sequence [...]

March 2022

February 2022

January 2022

December 2021

November 2021

October 2021

What is Peptide Mapping?

2022-11-17T16:15:11-05:00October 28th, 2021|Articles|

Peptide mapping is a widely used analytical technique to verify the primary structure (amino acid sequence) and characterize the chemical modifications of a protein. It analyzes peptides generated from the digestion of an isolated protein, or a protein mixture

September 2021

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October 2020

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April 2019