About Genya Gorshtein

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So far Genya Gorshtein has created 4 blog entries.

September 2022

Antibody Drug Conjugates as Anti-Cancer Therapeutics

2022-09-30T14:07:45-04:00September 19th, 2022|Articles|

Written by Genya Gorshtein, MSc September 14, 2022 Contents Introduction ADCs as Novel Anti-Cancer Chemotherapeutics Key Components of ADCs Future Generation of ADCs De Novo Protein Sequencing Applications in ADC Development Introduction An antibody-drug conjugate (ADC) is a monoclonal antibody (mAb) with a covalently attached cytotoxic payload [...]

August 2022

What Generates Antibody Diversity?

2022-09-01T12:31:12-04:00August 31st, 2022|Articles|

Written by Genya Gorshtein, MSc August 31, 2022 Contents Introduction Antibody Loci and V(D)J Recombination Somatic Hypermutation Class Switch Recombination De Novo Proteomic Sequencing of Antibodies Introduction Without the presence of an antigen, the human immune system can generate more than 1012 different antibodies and as many [...]

What are Polyclonal Antibodies?

2022-08-24T17:35:28-04:00August 18th, 2022|Articles|

Written by Genya Gorshtein, MSc August 18, 2022 Contents Introduction How are Polyclonal Antibodies Produced? Applications of Polyclonal Antibodies Challenges of Polyclonal Antibodies De Novo Polyclonal Antibody Sequencing Introduction Polyclonal antibodies (pAbs) are a heterogeneous mix of antibodies derived from B cells in the adaptive immune system. In [...]

Structure and Function of Antibodies

2022-08-24T17:37:21-04:00August 10th, 2022|Articles|

Written by Genya Gorshtein, MSc August 10, 2022 Contents General Structure of Antibodies Fab and Fc Fragments Hinge Region CDR and FR Regions Antibody Structure Analysis Services General Structure of Antibodies Antibodies or immunoglobulins (Ig) maintain a common quaternary structure consisting of two identical heavy chains (HCs) and two [...]