June 2024

Integrating AI and HDX-MS for Antibody Epitope Mapping

2024-06-10T11:40:08-04:00June 5th, 2024|Webinars|

July 11, 2024, 10:00AM EST | 16:00 CET In this webinar, you will learn: How AI and HDX-MS are applied in screening, epitope mapping, and selecting neutralizing antibodies against SARS-Cov-2. The predictive capabilities of AI computational modeling and its validation and refinement by high-resolution HDX-MS. How the integration of AI with HDX-MS [...]

May 2024

Ask Our Experts: Navigating Antibody Characterization through LC-MS

2024-06-10T12:44:02-04:00May 1st, 2024|Webinars|

In this webinar, you will… Learn the details of LC-MS based antibody characterization in early discovery and production pipelines Explore in-depth the analytical methodologies and strategies essential for comprehensive antibody characterization, covering post-translational modifications, glycan profiles, peptide mapping, and disulfide linkages Ask your burning questions and get expert guidance on navigating antibody [...]

February 2024

Maximizing Liquid Biopsy Sensitivity through the Power of DNA-Binding Antibodies

2024-04-24T10:33:09-04:00February 1st, 2024|Webinars|

In this webinar, you will learn: Non-Invasive Liquid Biopsies: Cell-free DNA as a key analyte for non-invasive liquid biopsies for cancer diagnosis and monitoring. Enhanced Cell-Free DNA Recovery: Strategies to improve cell-free DNA recovery, including the use of DNA priming agents like DNA-binding monoclonal antibodies. Fc-Domain Engineering: The process of engineering [...]

October 2023

New Antibody Characterization Essentials from Discovery to Clinic

2024-04-24T10:34:49-04:00October 4th, 2023|Webinars|

In this webinar, you will learn: Workflows for antibody characterization that extend beyond the primary amino acid sequence How to leverage HDX-MS for epitope mapping and SPR for binding kinetics to understand the mechanism of action and maximize the effectiveness of your characterization efforts How to ensure high-quality antibody production with [...]

August 2023

Latest Advancements in Antibody Engineering – Bispecifics, Diagnostic Controls, and More

2024-04-24T10:35:04-04:00August 29th, 2023|Webinars|

In this webinar, you will learn: Antibody technologies for the design of unique antibody formats Advancements in engineering efforts for the development of functionally tailored antibodies, recombinant isotype antibody panels, and multivalent fragment antibody constructs Characterization of different bispecific antibody formats Next generation protein sequencing to aid in bispecific antibody design [...]

July 2023

Antibody Discovery Dead Ends and New Approaches

2024-04-24T10:48:42-04:00July 20th, 2023|Webinars|

In this webinar, you will learn: About the challenges commonly encountered in antibody discovery campaigns, including non-functional antibodies, limited diversity, developability issues, and immunogenicity. How to de-risk antibody discovery campaigns, while balancing speed and spend Discover how a proteomics and mass spectrometry-based approach to antibody discovery, utilizing REpAb polyclonal sequencing, presents [...]

May 2023

Rational Antibody Design and Engineering with Next Generation Protein Sequencing

2024-04-29T13:20:11-04:00May 9th, 2023|Webinars|

In this webinar, you will learn: A strategy for generating recombinant mAbs and antibody derivatives directed towards antigens involved in mitotic cell division Methods for antibody engineering and customization, species switching, and construction of antibody fragments How Next Generation Protein Sequencing (NGPS) works Applications of NGPS to aid engineering and recombinant production of [...]

April 2023

The Shortcut to Reliable Diagnostic, Control, and Assay Antibodies

2024-04-25T10:09:41-04:00April 5th, 2023|Webinars|

In this webinar, you will learn: IVD and immunoassays, supply chain risk management considerations How monoclonal and polyclonal antibody sequencing works, requirements Effective production, validation, and scale-up of recombinant antibody reagents Characterization of mAbs for assay design Abstract Polyclonal antibodies (pAbs) are well known for their robustness and [...]

Navigating Intellectual Property Protection for Antibodies

2024-05-06T15:50:21-04:00April 1st, 2023|Webinars|

In This Webinar, You Will Learn: Why IP is important in the development of antibody-based assets Patent application process and requirements How to strengthen patent applications Applications of De Novo Protein Sequencing, SPR assays, and HDX-MS for antibody-related patent applications Abstract In the development of novel and innovative antibody-based assets, [...]

February 2023

Nanobody Lead Optimization with Epitope Mapping and Binning

2024-05-06T15:59:33-04:00February 14th, 2023|Webinars|

In this webinar, you will learn: How Rapid Novor’s de novo polyclonal sequencing platform REpAb® can accelerate any nanobody development pipeline How SPR and HDX-MS integrate into an antibody discovery and development workflow How to choose optimal lead candidates with SPR and HDX-MS How epitopes can be characterized using SPR and HDX-MS [...]

October 2022

September 2022

Characterizing Fragile Protein Complexes

2024-04-24T10:43:28-04:00September 14th, 2022|Webinars|

Webinar Highlights You will learn: Introduction to the structure and function of the tuberous sclerosis protein complex (pTSC) A novel strategy for isolating and purifying protein complexes from native sources using recombinantly produced Fabs How Next Generation Protein Sequencing (NGPS) works Applications of NGPS to aid design and engineering of recombinant antibody [...]

July 2022

Next Generation Vaccine Development with Proteomics

2024-04-24T10:43:40-04:00July 5th, 2022|Webinars|

As nearly all individuals have pre-existing immunity to influenza viruses, influenza-specific memory B cells will likely be recalled upon COBRA HA vaccination. By comparing the antibody response towards specific wild-type influenza strains and COBRA antigens, we can begin to understand the potential for COBRA-based vaccines to be used in the clinic.

May 2022

Enriching Engineered T Cells with Antibody Sequencing & Modulation

2024-04-24T10:56:54-04:00May 10th, 2022|Webinars|

Known, high-performing and well used antibodies against useful targets on CAR-T cells can be examined for mechanism of action using proteomics and mass spectrometry. Knowledge of the antibody sequences via Next Generation Protein Sequencing (NGPS) can be useful for humanizing or otherwise engineering constructs. Rapid Epitope mapping by HDX can be useful for both epitope and paratope engineering strategies.

March 2022

February 2022

January 2022

Why Is Sequence Blindness Acceptable with Antibodies?

2024-04-24T10:57:47-04:00January 30th, 2022|Webinars|

There have been cases where researchers have trusted a kit, and they see a positive reaction only to, unfortunately, realize that the kit was actually detecting another protein because the kit’s antibody lot changed. Such was the case for the University of Toronto’s Diamandis team who spent half a million dollars and nearly two years due to an unreliable antibody. A certificate proving that the protein sequence of an antibody remains unchanged would have easily avoided the aforementioned mishaps.

Recombinant Therapeutic pAbs are Now Possible

2024-04-24T10:58:06-04:00January 20th, 2022|Webinars|

Polyclonal antibodies are popular research reagents for their high sensitivity and robust cross-platform performance. But few companies consider them viable for therapeutic applications as they are almost impossible to characterize. Additionally, they suffer from a lack of reproducibility and limited supply. Monoclonal antibodies (mAbs) can be reliably characterized and produced for therapeutic applications, but are more costly to discover and develop. Rapid Novor’s REpAb technology can overcome these limitations by capturing the sequences of the most abundant IgG in a pAb and enabling indefinite antibody production. Here we report the first successful conversion of a goat polyclonal antibody into a cocktail of recombinant mAbs using only the pAb protein sample.

December 2021

Polyclonal Antibody Sequencing in Therapeutics Development Pipelines

2024-04-25T10:13:31-04:00December 20th, 2021|Webinars|

Over the past several years Rapid Novor has been developing the world's best antibody protein sequencing platform, with over 2700 monoclonal antibodies and proteins sequenced. In 2020, they unveiled their most advanced technology to date- REpAb® polyclonal antibody sequencing. The platform combines the world's best protein sequencing technology and NGS to comprehensively mine the antigen specific antibody repertoire present in rabbit and human patient samples. By leveraging the platform, teams can build robust antibody assays and therapeutic leads derived from patient's blood.

September 2021

July 2021

Fully Harnessing the Power of Immunotherapy through Protein Sequencing

2024-04-24T10:59:22-04:00July 20th, 2021|Webinars|

Of interest to human and veterinary drug development scientists, biologics and biosimilars development scientists, scientists performing pre-clinical assay development, immunotherapy researchers, oncolytic therapy development scientists, gene therapy development scientists, gene therapy, and oncolytic therapy researchers, CAR-T, and CAR-NK development scientists

May 2021

Polyclonal Antibody Sequencing with Only Proteomics

2024-04-25T10:12:57-04:00May 13th, 2021|Webinars|

Over the past 5 years Rapid Novor has perfected monoclonal antibody sequencing, and is now sequencing mAbs from polyclonal mixtures using REpAb®.  After successfully launching their proteogenomics based sequencing technology to deconvolute the immune response, the team has further evolved the technology and has derived the most abundant mAb sequences directly from rabbit blood using only proteomics. The talk will surround the development, progress and use cases for REpAb®.

April 2021

Non-Fungible Antibodies

2024-04-24T10:59:40-04:00April 20th, 2021|Webinars|

Other than a paucity in widespread use, such efforts still do not address the main issue: the uniqueness of antibodies. Unlike currency, antibodies are non-fungible. To manufacture a replica of a specific antibody, we must first know its sequence. Sometimes, scientists may obtain the sequence through nucleotide sequencing means.

Leveraging pAbs for Therapeutic Development

2024-04-24T10:59:59-04:00April 13th, 2021|Webinars|

Over the past several years Rapid Novor has been developing the world’s best antibody protein sequencing platform, sequencing over 2700 monoclonal antibodies and proteins. In 2020, they unveiled their most advanced technology to date - REpAb® polyclonal antibody sequencing. The platform combines the world’s best protein sequencing technology and NGS to comprehensively mine the antigen-specific antibody repertoire present in rabbit and human patient samples. By leveraging the platform, teams can build robust antibody assays and therapeutic leads derived from patients’ blood.

March 2021

Leveraging Polyclonal Antibody Sequencing to Get High Affinity Binders Against Tough Targets

2023-06-21T10:56:04-04:00March 13th, 2021|Webinars|

When it comes to polyclonal antibodies, how they are discovered can be just as important as how they are reproduced. In our talk originally presented at Antibody Engineering & Therapeutics Digital 2021, we highlighted the latest technology that’s capable of capturing the most abundant and high-affinity monoclonal antibodies directly from a poly mixture.

January 2021

November 2020

October 2020

Research Insurance with De Novo Protein Sequencing

2024-04-01T15:50:35-04:00October 3rd, 2020|Webinars|

If you could have guaranteed stability, certainty, and reproducibility for your research, would you be interested? Imagine this, if you’re 2 years into your project and your freezer died along with all of your important cell lines, what would you do? This is just one of the situations covered in this webinar, along with many other solutions researchers have begun to implement to safeguard their efforts. Whether you’re looking to proceed with stability and certainty or you’re looking for an immediate solution for your current reproducibility challenges, protein sequencing may be the answer.

September 2020

May 2020

Introduction to De Novo Protein Sequencing

2023-06-21T10:54:37-04:00May 21st, 2020|Webinars|

In this on-demand webinar, our scientific sales executive Jennifer, will briefly cover the fundamentals of protein sequencing, how researchers have benefited from implementing protein sequencing into their pipelines, and discuss how Rapid Novor is able to routinely and robustly achieve 100% accuracy and 100% coverage for both monoclonal and oligoclonal antibodies.

April 2019