Antibody Engineering2022-08-19T14:07:04-04:00

Antibody Engineering.

Minimize immunogenicity.

Advancements in protein sequencing technologies make it possible to work off of the exact amino acid sequence of any antibody species, allowing easy modification. This knowledge both enables and simplifies grafting any host regions of interest onto a desired backbone.

Next generation protein sequencing (NGPS) continues to facilitate recombinant expression to ease manipulation and engineering. More importantly, when modifications, mispairings, or mutations occur through time, proteomics can also help confirm the protein sequence in every step throughout the therapeutic pipeline.

Research teams are using NGPS for therapeutic and diagnotic projects focused on humanization and/or chimerization of antibodies, development of nanobodies, scvFs, and/or engineering of bi/tri/multi-specific antibodies.

Webinar

Rational Antibody Design and Engineering with Next Generation Protein Sequencing

Oct 20, 11 am EST

Services for Antibody Engineering.

We support the antibody engineering efforts of life science companies in all stages of development. Contact Us to discover how we can help with your antibody engineering application.

Antibody Sequencing & Discovery Services.

de novo mAb Sequencing

Obtain amino acid sequences of functional antibodies to facilitate in silico design, rational engineering, humanization, chimerization, affinity maturation, conjugation design and construction of fragments and multi-specifics.
Explore REmAb

Novel mAb Discovery

Mine the functional native immune response by directly sequencing and accessing patient antibodies and discover novel mAb candidates for downstream engineering efforts.
Explore REpAb

Validate Engineered mAb Constructs

Confirm protein sequences and pinpoint the occurrences of any modifications, mispairings, or mutations after protein expression or during cell line development. Minimize troubleshooting efforts with real-time peptide mapping.
Explore MATCHmAb

Binding Kinetics

Test, assess, and evaluate mAb binding kinetic properties (ie. specificity, affinity, efficiency) to evaluate and reevaluate engineering strategies.
Explore SPR Analysis

Epitope Mapping

Characterize antigenic epitopes for the rational design of mAbs, scFvs, and multi-specifics. Determine antibody binding sites on target antigens for FDA and EMEA regulatory filings and IP protection.
Explore HDX-MS

Recombinant Expression

Indefinitely store the amino acid sequence and recombinantly express the engineered mAb in a streamlined workflow, securing product supply.
Explore Antibody Expression

Application Publications.

“We’re focused on coupling cytokines with a highly engineered VHVL of an antibody. So by sequencing the antibodies with Rapid Novor we are able to pull out the CDR to graft them into our platform and test in vitro and in vivo.”

Pavel Khrimian – Co-founder and CBO, Deka Biosciences

Talk to Our Scientists.

We Have Sequenced 6000+ Antibodies and We Are Eager to Help You.

Through next generation protein sequencing, Rapid Novor enables reliable discovery and development of novel reagents, diagnostics, and therapeutics. Thanks to our Next Generation Protein Sequencing and antibody discovery services, researchers have furthered thousands of projects, patented antibody therapeutics, and developed the first recombinant polyclonal antibody diagnostics.

Talk to Our Scientists.

We Have Sequenced 6000+ Antibodies and We Are Eager to Help You.

Through next generation protein sequencing, Rapid Novor enables timely and reliable discovery and development of novel reagents, diagnostics, and therapeutics. Thanks to our Next Generation Protein Sequencing and antibody discovery services, researchers have furthered thousands of projects, patented antibody therapeutics, and ran the first recombinant polyclonal antibody diagnostics

Talk to our scientists. We have sequenced over 6000 antibodies and we are eager to help you.