Case StudiesMingjie Xie2024-10-11T15:28:02-04:00

Case Studies.

Learn how other scientists have achieved success using our technology. We’ll also share our own peer reviewed studies.

Developing Diagnostic Tools for Challenging MGTS Cases

Tags: diagnostics, in vitro diagnostics, IVD, MGTS, Monoclonal antibody sequencing, Monoclonal gammopathy of thrombotic significance, Recombinant expression, recombinant mAbs, REmAb|

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Antibody Discovery in Humans – Starting with Functional, Circulating Antibodies

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Discover the latest case studies.

Antibody Affinity Insights with REpAb Antibody Discovery

Genya Gorshtein2025-04-02T09:21:49-04:00Tags: affinity, antibody affinity, Antibody discovery, Antibody drug discovery, Antibody therapeutics, Kinetic analysis, Polyclonal antibody sequencing, Polyclonal sequencing, REpAb, SPR, Technology|

De Novo Sequencing a Bispecific T Cell Engager

Genya Gorshtein2025-01-27T11:21:12-05:00Tags: Antibody therapeutics, bispecific antibody, bispecific t cell engager, Monoclonal antibody, Monoclonal antibody sequencing, REmAb, sequence validation, t cell engager, Technology|

NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

Genya Gorshtein2024-11-08T14:30:46-05:00Tags: Antibody development, Antibody engineering, antibody sequencing, Antibody therapeutics, Cell therapy, EGFR, HLA alleles, HLA-E, MHC, Monoclonal antibody sequencing, REmAb|

De Novo Protein Sequencing of Antibodies for Identification of Neutralizing Antibodies in Human Plasma Post SARS-CoV-2 Vaccination

Genya Gorshtein2024-12-03T12:03:32-05:00Tags: Antibody characterization, Antibody development, Antibody discovery, Antibody therapeutics, B cell sequencing, B-cells, covid-19, Featured, Human antibodies, human antibody discovery, Polyclonal sequencing, REpAb, serum sequencing|

DAR Analysis of TRBC1-Targeting Antibody–Drug Conjugates

Genya Gorshtein2025-04-30T11:47:09-04:00Tags: ADCs, Antibody characterization, Antibody development, Antibody Drug Conjugates, Antibody therapeutics, DAR, DAR analysis, LC-MS|

Cell-Free Methods of Producing Antibodies to Intracellular Targets

Genya Gorshtein2024-05-23T11:07:14-04:00Tags: Antibody engineering, Antibody therapeutics, De novo sequencing, Monoclonal antibody, Recombinant antibodies, Recombinant expression, REmAb|

Generation and Optimization of Off-The-Shelf Immunotherapeutics Targeting TCR-Vβ2+ T Cell Malignancy

Genya Gorshtein2024-04-24T10:31:27-04:00Tags: Antibody engineering, Antibody therapeutics, CAR-T, De novo sequencing, Monoclonal antibody, REmAb|

Priming Agents Transiently Reduce the Clearance of Cell-Free DNA to Improve Liquid Biopsies

Genya Gorshtein2024-04-24T10:31:44-04:00Tags: Antibody engineering, De novo sequencing, in vitro diagnostics, IVD, Monoclonal antibody, REmAb|

Combined Analytical Assays for the Characterization of Drugs Binding to Human IgE: Applicability to Omalizumab-bearing Biosimilar Candidates Assessment

Genya Gorshtein2024-04-24T10:33:29-04:00Tags: Antibody engineering, Biosimilars, Characterization, De novo sequencing, Monoclonal antibody, Recombinant expression, REmAb, SPR|

Alpaca Antibody Discovery and Characterization with Polyclonal Sequencing, SPR and HDX-MS

Mingjie Xie2024-12-03T14:07:09-05:00Tags: Antibody characterization, Antibody discovery, HDX-MS, REpAb, SPR. Polyclonal sequencing|

Confirming the Binding Site Between Cellular DNA Repair Proteins with HDX-MS

Genya Gorshtein2024-05-06T16:01:28-04:00Tags: Antibody characterization, binding site, Epitope mapping, HDX-MS, paratope|

Antibody Discovery from a Chicken Polyclonal Mixture

Genya Gorshtein2024-12-03T12:05:05-05:00Tags: Antibody discovery, Antibody generation, Biologics Drug Discovery, chicken, De novo sequencing, REpAb|

Single-Molecule Characterization of Subtype-Specific β1 Integrin Mechanics

Mingjie Xie2024-04-24T10:37:05-04:00Tags: AbEng, Antibody engineering, Antibody generation, De novo sequencing, Monoclonal antibody, Recombinant expression, REmAb|

CAR-iNKT Cells Targeting Clonal TCRVβ Chains as a Precise Strategy to Treat T Cell Lymphoma

Mingjie Xie2024-06-10T12:48:41-04:00Tags: AbEng, Antibody engineering, Antibody generation, CAR-T, De novo sequencing, Monoclonal antibody, Recombinant expression, REmAb, Technology|

Evaluation and Selection of a Lead Diabody for Interferon-γ PET Imaging

Mingjie Xie2024-04-24T10:38:00-04:00Tags: Antibody engineering, Antibody generation, De novo sequencing, Monoclonal antibody, Recombinant expression, REmAb|

Exploring the Sheep (Ovis aries) Immunoglobulin Repertoire by Next Generation Sequencing

Mingjie Xie2024-04-24T10:41:40-04:00Tags: Antibody discovery, Monoclonal antibody, Next-generation sequencing, Polyclonal antibody, Sheep, Vet med|

Towards Antigen-Specific Tregs for Type 1 Diabetes: Construction and Functional Assessment of Pancreatic Endocrine Marker, HPi2-Based Chimeric Antigen Receptor

Mingjie Xie2024-04-24T10:42:26-04:00Tags: Antibody characterization, Antibody engineering, CAR-T, De novo sequencing, Monoclonal antibody, REmAb|

Structural Characterization of Endogenous Tuberous Sclerosis Protein Complex Revealed Potential Polymeric Assembly

Mingjie Xie2024-04-24T10:42:58-04:00Tags: Antibody characterization, Antibody engineering, Application, De novo sequencing, Monoclonal antibody, REmAb|

Resistance to Autosomal Dominant Alzheimer’s Disease in an APOE3 Christchurch Homozygote

Mingjie Xie2024-04-24T10:43:19-04:00Tags: Antibody engineering, Antibody generation, Antibody therapeutics, De novo sequencing, Monoclonal antibody, REmAb|

Characterization and Modulation of Anti-αβTCR Antibodies and Their Respective Binding Sites at the βTCR Chain to Enrich Engineered T Cells

Mingjie Xie2024-04-24T10:43:50-04:00Tags: Antibody engineering, CAR-T, De novo sequencing, Monoclonal antibody, REmAb|

Broadly Neutralizing Antibody Cocktails Targeting Nipah Virus and Hendra Virus Fusion Glycoproteins

Mingjie Xie2024-04-24T10:43:58-04:00Tags: Antibody discovery, Antibody engineering, De novo sequencing, Monoclonal antibody, REmAb, Vet med|

Generation and Diversification of Recombinant Monoclonal Antibodies

Mingjie Xie2024-04-29T13:20:43-04:00Tags: Antibody engineering, Antibody generation, De novo sequencing, Monoclonal antibody, Recombinant expression, REmAb, Target validation|

First Immunoassay for Measuring Isoaspartate in Human Serum Albumin

Mingjie Xie2024-04-24T10:57:11-04:00Tags: Antibody characterization, Antibody discovery, De novo sequencing, IVD, REmAb|

Sequencing and Recombinant Expression of Goat Antibodies from a Polyclonal Mixture

Mingjie Xie2024-12-03T12:20:41-05:00Tags: Antibody characterization, Antibody discovery, De novo sequencing, Goat, Monoclonal antibody, Polyclonal antibody, Recombinant expression, REpAb, Vet med|

All Posts.

Developing Diagnostic Tools for Challenging MGTS Cases

Genya Gorshtein2025-05-16T09:54:28-04:00Categories: Case Studies|Tags: diagnostics, in vitro diagnostics, IVD, MGTS, Monoclonal antibody sequencing, Monoclonal gammopathy of thrombotic significance, Recombinant expression, recombinant mAbs, REmAb|

Cytokines in Disease and Therapeutics

Jenna Kerry2025-05-09T17:32:20-04:00Categories: Articles|Tags: autoimmune disease, cytokine therapeutics, cytokines, immune function, immune system, immunocytokines, Learning, Protein characterization, Protein sequencing, vaccine development|

Anti-Idiotypic Antibodies in Drug Development

Genya Gorshtein2025-04-09T13:16:36-04:00Categories: Articles|Tags: ADA assays, anti-drug antibodies, anti-idiotypic antibodies, antibody reagents, Drug development, functional antibodies, immunogenicity assays, Learning, pharmacokinetics, PK assays, REpAb|

Disulfide Bond Engineering

Jenna Kerry2025-04-04T11:50:52-04:00Categories: Articles|Tags: antibody stability, antibody structure, Disulfide bond, Disulfide bond analysis, disulfide scrambling, disulfide shuffling, Learning, Post-translational modification, Protein characterization, Protein sequencing, vaccine development|

Antibody Affinity Insights with REpAb Antibody Discovery

Genya Gorshtein2025-04-02T09:21:49-04:00Categories: Case Studies|Tags: affinity, antibody affinity, Antibody discovery, Antibody drug discovery, Antibody therapeutics, Kinetic analysis, Polyclonal antibody sequencing, Polyclonal sequencing, REpAb, SPR, Technology|

Major Histocompatibility Complex Therapeutic Applications

Jenna Kerry2025-04-04T11:53:52-04:00Categories: Articles|Tags: AI, antibody, De novo sequencing, immune function, immune system, immunopeptidomics, Immunotherapy, Learning, major histocompatibility complex|

Interview with Dr. Dominic Narang, Senior Scientist of HDX-MS Services

Genya Gorshtein2025-03-24T16:54:33-04:00Categories: Articles|Tags: antibody epitopes, Dominic Narang, Epitope mapping, HDX-MS, HDX-MS Epitope Mapping, Learning, Paratope Mapping, Scientist Interview, Scientist Profile|

Major Histocompatibility Complex

Jenna Kerry2025-03-06T16:01:22-05:00Categories: Articles|Tags: AI, antibody, De novo sequencing, immune function, immune system, immunopeptidomics, Immunotherapy, Learning, major histocompatibility complex|

Antibody Tools for Target Identification and Validation

Genya Gorshtein2025-03-24T16:55:02-04:00Categories: Articles|Tags: Antibody engineering, antibody reagents, basic research, biomarker discovery, custom antibody development, Drug development, Learning, mAb tools, target identification, Target validation, tool antibodies|

De Novo Sequencing a Bispecific T Cell Engager

Genya Gorshtein2025-01-27T11:21:12-05:00Categories: Case Studies|Tags: Antibody therapeutics, bispecific antibody, bispecific t cell engager, Monoclonal antibody, Monoclonal antibody sequencing, REmAb, sequence validation, t cell engager, Technology|

Phage Display Antibody Discovery

Jenna Kerry2025-01-02T12:57:28-05:00Categories: Articles|Tags: AI, antibody, Antibody characterization, Antibody development, Antibody discovery, Antibody drug discovery, Antibody engineering, antibody epitopes, antibody function, Antibody humanization, Antibody therapeutics, Bacteriophage Display, Immunotherapy, Learning, Phage Display, Phage Display Antibody Discovery, Phage Display Antibody Library, Phage Display Library, Phage Display Technology, Phage Panning, Polyclonal antibody sequencing|

B Cells and Their Antibodies

Genya Gorshtein2025-03-24T16:56:21-04:00Categories: Articles|Tags: Antibody discovery, antibody discovery methods, antibody discovery platform, B cell sequencing, B-cells, Learning, NGS, Polyclonal antibody sequencing, Polyclonal sequencing, proteogenomics, REpAb, serum, serum antibodies, single b cell sequencing|

B Cell Sequencing and Polyclonal Sequencing Explained

Genya Gorshtein2024-12-09T17:57:13-05:00Categories: Articles|Tags: Antibody discovery, antibody discovery methods, antibody discovery platform, B cell sequencing, B-cells, NGS, Polyclonal antibody sequencing, Polyclonal sequencing, proteogenomics, REpAb, single b cell sequencing, Technology|

NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

Genya Gorshtein2024-11-08T14:30:46-05:00Categories: Case Studies|Tags: Antibody development, Antibody engineering, antibody sequencing, Antibody therapeutics, Cell therapy, EGFR, HLA alleles, HLA-E, MHC, Monoclonal antibody sequencing, REmAb|

Antibody Humanization Strategies, Challenges, and Innovations

Jenna Kerry2024-12-11T10:12:25-05:00Categories: Articles|Tags: AI, antibody, Antibody characterization, Antibody development, Antibody discovery, Antibody drug discovery, Antibody engineering, antibody epitopes, antibody function, Antibody humanization, Antibody therapeutics, B cell sequencing, Immunotherapy, Learning, Polyclonal antibody sequencing|

Comparing Epitope Mapping Methods

Genya Gorshtein2025-03-24T16:57:39-04:00Categories: Articles|Tags: Antibody Epitope, Binding Epitope, Cryo-EM, Epitope mapping, Epitope Mapping Methods, FPOP-MS, functional characterization, HDX, HDX-MS, HDX-MS Epitope Mapping, Learning, Method Comparison, Paratope Mapping, X-Ray, XL-MS|

De Novo Protein Sequencing of Antibodies for Identification of Neutralizing Antibodies in Human Plasma Post SARS-CoV-2 Vaccination

Genya Gorshtein2024-12-03T12:03:32-05:00Categories: Case Studies|Tags: Antibody characterization, Antibody development, Antibody discovery, Antibody therapeutics, B cell sequencing, B-cells, covid-19, Featured, Human antibodies, human antibody discovery, Polyclonal sequencing, REpAb, serum sequencing|

De Novo Antibody Sequencing Reveals Novel Functional and Neutralizing Antibodies Post-SARS-CoV-2 Vaccination

Genya Gorshtein2024-10-11T10:03:08-04:00Categories: News|

Trick or Treat: Unmasking Antibody Reproducibility in Life Sciences

Genya Gorshtein2024-12-16T17:29:22-05:00Categories: Webinars|Tags: antibody reproducibility, Learning, Monoclonal antibody, pAb, Polyclonal antibody, Polyclonal antibody sequencing, Recombinant expression, REpAb, Reproducibility, reproducibility crisis, Target validation, tool antibodies|

Agonist Antibody Challenges and Optimization

Jenna Kerry2024-10-01T17:08:33-04:00Categories: Articles|Tags: agonist, agonistic antibodies, antibody, Antibody characterization, Antibody development, Antibody discovery, Antibody engineering, antibody epitopes, antibody function, Antibody therapeutics, Epitope mapping, Immunotherapy, Learning, Polyclonal antibody sequencing|

Best Hosts for Antibody Discovery and Generation

Genya Gorshtein2024-12-03T14:47:53-05:00Categories: Articles|Tags: Antibody discovery, antibody discovery hosts, Antibody drug discovery, antibody formats, Antibody generation, antibody generation hosts, antibody host, Antibody therapeutics, best hosts, epitope diversity, Learning, REpAb, species agnostic, Vet med|

Antagonistic Antibodies: Opportunities and Obstacles

Jenna Kerry2024-12-02T13:27:16-05:00Categories: Articles|Tags: antagonistic antibodies, Antibody characterization, Antibody discovery, Antibody drug discovery, Antibody engineering, antibody function, Antibody generation, Antibody therapeutics, De novo sequencing, Learning, Monoclonal antibody, Next generation protein sequencing, quality control, Recombinant expression, regulatory compliance, Reproducibility|

Sequence Variant Analysis of Monoclonal Antibodies

Genya Gorshtein2024-08-09T14:29:53-04:00Categories: Articles|Tags: Antibody characterization, Antibody drug discovery, Antibody therapeutics, cell culture, Learning, protein sequence variants, protein variants, Recombinant expression, regulatory, regulatory compliance, sequence variant analysis, Sequence variants, SVA|

Detecting and Preventing Disulfide Scrambling in Monoclonal Antibodies

Jenna Kerry2024-12-02T13:40:48-05:00Categories: Articles|Tags: De novo sequencing, Disulfide bond, Disulfide bond analysis, disulfide scrambling, disulfide shuffling, HPLC-MS/MS, Learning, Monoclonal antibody, Next generation protein sequencing, quality control, Recombinant expression, regulatory compliance, Reproducibility|

Interview with Dr. Thierry Le Bihan, Principal Scientist in Polyclonal Antibody Sequencing

Genya Gorshtein2025-01-03T15:31:45-05:00Categories: Articles|Tags: Antibody discovery, Antibody drug discovery, Polyclonal antibody sequencing, Polyclonal sequencing, REpAb, Scientist Interview, Scientist Profile, Thierry Le Bihan|

Talk to Our Scientists.

We Have Sequenced 10,000+ Antibodies and We Are Eager to Help You.

Through next generation protein sequencing, Rapid Novor enables reliable discovery and development of novel reagents, diagnostics, and therapeutics. Thanks to our Next Generation Protein Sequencing and antibody discovery services, researchers have furthered thousands of projects, patented antibody therapeutics, and developed the first recombinant polyclonal antibody diagnostics.

Talk to Our Scientists.

We Have Sequenced 9000+ Antibodies and We Are Eager to Help You.

Through next generation protein sequencing, Rapid Novor enables timely and reliable discovery and development of novel reagents, diagnostics, and therapeutics. Thanks to our Next Generation Protein Sequencing and antibody discovery services, researchers have furthered thousands of projects, patented antibody therapeutics, and ran the first recombinant polyclonal antibody diagnostics

Talk to our scientists. We have sequenced over 9000+ antibodies and we are eager to help you.