Antibody Sequencing Services2022-08-11T14:08:38-04:00

Antibody Sequencing Service.

Our antibody sequencing services can determine the amino acid sequence of monoclonal or polyclonal antibodies with our proprietary high-throughput, full coverage de novo antibody sequencing technology.

Established Antibody Sequencing Platform.

Our REmAb® and REpAb® solutions are built on a strong foundation of over 20 years of mass spectrometry and bioinformatics expertise. We foster continuous innovation. Our patented protein chemistry protocols and proprietary big data machine learning algorithms facilitate novel discoveries, empowering our clients to further their research faster and more confidently.

High-Throughput, Uncompromisingly Accurate.

REmAb®’s core strength is its uncompromising accuracy. Thousands of overlapping peptides support the protein sequence, which is why we can confidently claim 100% accuracy. REmAb®’s fast and robust platform fuels trailblazing research worldwide.

Enabling and Safeguarding Discoveries.

A consistently reliable antibody is one of a kind. With REmAb® and REpAb®, researchers have the choice to use mAbs and pAbs without being blind to protein sequence information – thereby safeguarding results for project continuance, patents, regulatory approvals, and antibody production

Monoclonal Antibody Sequencing vs. Polyclonal Antibody Sequencing

mAb Sequencing – REmAb®

REmAb® is our monoclonal antibody sequencing service, proven 100% accurate over 5000+ antibodies.
Explore REmAb (below)

pAb Sequencing – REpAb®

REpAb® is the worlds’ first polyclonal antibody sequencing service. Sequence antibodies from a polyclonal mixture or immunized serum.
Explore REpAb (bottom)

REmAb® Monoclonal Antibody Sequencing

How It Works.

The REmAb® workflow delivers a full coverage antibody sequence with unparalleled accuracy, 100% of the time (see sample requirements below). Starting with only a small sample of protein, we conduct proprietary chemistry, LC-MS/MS proteomics and machine-learning driven sequencing.

Turn-around time

11+ samples, 4 weeks
2-10 samples, 3 weeks
1 sample, 2 weeks
Rush, 1 week

Requirements

Any species

Any antibody isotype

100 μg of protein, >80% purity

Is your sample smaller or less pure?

Ask us
. We can often still get results.

Deliverables

The entire mAb sequence averaging 30X coverage per amino acid. Sample coverage view.

Independent review – sequences derived by proprietary bioinformatics and expert reviews.

Isobaric checks – all isobaric combinations are determined by WILD®.

REpAb® Polyclonal Antibody Sequencing

How It Works.

Starting with an affinity purified polyclonal antibody sample, we perform proprietary separation chemistry, numerous mass spectrometry analyses and advanced bioinformatics to derive the full-length chain-paired sequences.

Turn-around Time

2-5 months

Depending on the number of stages progressed.

Requirements

1mg of antigen affinity purified polyclonal antibody. Providing 3-5 ml of blood is an option if available to you. Alternatively we can start with the antigen and conduct an immunization with REpAb in an Antibody Discovery Service workflow.


Ask us
. We can work with less, depending on the sample and the antigen. Not every pAb is of sufficient quality sequencing. We’ll start with a screening.

Deliverables

Deliverables can include the full mAb sequences with heavy and light chains properly paired, CDR clusters, NGS data, recombinantly expressed antibodies, and antigen binding results (depending on the options you select).

Pricing.

REmAb: List Price

$13000
  • Bulk Order Discounts Available
  • (Optional) +$1000 MATCHmAb™ **
  • (Optional) +$2000 Rush Order
  • (Optional) Recombinant Expression
  • Ask about add-ons for: non-antibody protein sequencing, intact mass analysis, PTM studies, etc.

REmAb: Intro Offer

$4999
  • First Time Customers Only, IgG only.
  • (Optional) +$1000 MATCHmAb™ **
  • (Optional) +$2000 Rush Order
  • (Optional) Recombinant Expression
  • Ask about add-ons for: non-antibody protein sequencing, intact mass analysis, PTM studies, etc.

REpAb

Ask
  • Immunization and/or purification option
  • Sample screening and initial sequencing
  • Deep sequencing
  • Recombinant expression (option)
  • Please talk to one of our scientists to tailor the service to your unique needs.

REmAb® has saved hundreds of hybridomas and contributed to dozens of papers and helped create products and patents worth millions of dollars.

REpAb® is the first and only technology demonstrated to sequence pAbs using mass spectrometry, and without reference to nucleotide sequences. The resulting recombinant antibodies perform as well as the original pAb.

We’re #1 in the world for de novo sequencing.

6000+ projects completed
100+ samples processing at any moment
100% satisfaction rate

“Rapid Novor was tasked with finding highly specific, high affinity antibodies against an important target- and they delivered powerful antibodies fit-for-purpose. Such antibodies are not easily obtained yet the Rapid Novor approach proved immediately successful, despite our time-constrained and stringent demands.”

Matt Pope, VP of Client Services, SISCAPA

“We’re focused on coupling cytokines with a highly engineered VHVL of an antibody. So by sequencing the antibodies with Rapid Novor we are able to pull out the CDR to graft them into our platform and test in vitro and in vivo.”

Pavel Khrimian – Co-founder and CBO, Deka Biosciences

“The sequences have allowed us to have an “insurance policy” of sorts for critical proteins used in our various products.”

David Ankrapp, Senior Research Scientist, Neogen Corporations

Learn More.

Broadly Neutralizing Antibody Cocktails Targeting Nipah Virus and Hendra Virus Fusion Glycoproteins

Hendra virus (HeV) and Nipah virus (NiV) are types of Henipaviruses (HNVs) that originated in bats and can infect the human respiratory system with detrimental consequences. As enveloped, single-stranded RNA viruses, HeV and NiV use attachment (G) and fusion (F) glycoproteins on the envelope membrane to enter host cells. So far, there are no approved therapeutics or vaccines to combat the viruses in humans.

Talk to Our Scientists.

We Have Sequenced 6000+ Antibodies and We Are Eager to Help You.

Through next generation protein sequencing, Rapid Novor enables reliable discovery and development of novel reagents, diagnostics, and therapeutics. Thanks to our Next Generation Protein Sequencing and antibody discovery services, researchers have furthered thousands of projects, patented antibody therapeutics, and developed the first recombinant polyclonal antibody diagnostics.

Talk to Our Scientists.

We Have Sequenced 6000+ Antibodies and We Are Eager to Help You.

Through next generation protein sequencing, Rapid Novor enables timely and reliable discovery and development of novel reagents, diagnostics, and therapeutics. Thanks to our Next Generation Protein Sequencing and antibody discovery services, researchers have furthered thousands of projects, patented antibody therapeutics, and ran the first recombinant polyclonal antibody diagnostics

Talk to our scientists. We have sequenced over 6000 antibodies and we are eager to help you.

Antibody Sequencing, Discovery and Proteomics Services.

Antibody Sequencing & Discovery Services.

REmAb®

Monoclonal antibody sequencing from small protein samples, no need for hybridoma or DNA information. Full sequence in record time.
Explore REmAb

REpAb®

Polyclonal antibody sequencing and antibody discovery service. Sequence antibodies from blood or a polyclonal mixture.
Explore REpAb

MATCHmAb

Antibody verification by real-time peptide mapping. Antibody sequence confirmation service for reproducibility.
Explore MATCHmAb

HDX-MS

Mass spec based epitope mapping. Epitope mapping for identify the binding site of an antibody to its corresponding antigen with the highest confidence and resolution.
Explore Epitope Mapping

SPR Analysis

Label-free evaluation of antibody-antigen binding relies on a Surface Plasmon Resonance technology. Combined with our expertise in antibody interactions, this results in high sensitivity and the lowest noise even in complex analytes.
Explore SPR Analysis

NovorIg™

Quantify the immune response by accurately profiling the vast antibody-protein repertoire and its different isotypes, and subtypes in serum over time.
Explore Immune Response Profiling