December 2022

The Hunt for Novel Therapeutics Through Antibody Engineering

2022-12-02T11:22:32-05:00December 2nd, 2022|Articles|

Written by Genya Gorshtein, MSc November 1, 2022 Contents Introduction Approaches for Engineering Antibody Therapeutics Driving Antibody Engineering with Next Generation Protein Sequencing and Proteomics Introduction Antibody engineering encompasses various development, production strategies, and modification techniques to improve the biological properties of monoclonal antibodies (mAbs) as therapeutic [...]

Cell Specific Protein Degradation with Antibody Conjugated PROTACs

2022-12-02T10:23:52-05:00December 2nd, 2022|Articles|

Written by Genya Gorshtein, MSc November 25, 2022 Contents Introduction General PROTAC Structure and Function Antibody-Conjugated PROTACs Developing AbPROTACs with De Novo Antibody Sequencing and Proteomics Introduction Small-molecule drug development is aimed at inhibiting disease-promoting protein function through occupancy-driven protein inhibition. A major caveat of this therapeutic [...]

July 2022

Protein Characterization by HDX-MS

2022-10-27T11:20:06-04:00July 26th, 2022|Articles|

Written by Vanessa Yoon Calvelo, PhD July 21, 2022 Contents Mass spectrometry-based approaches for structural analysis of proteins HDX-MS Applications for ‘Difficult’ Proteins HDX-MS – A powerful analytical technique for protein characterization Mass spectrometry-based approaches for structural analysis of proteins Characterization of proteins and protein complexes is [...]

June 2022

Protein Structure and How to Study it

2022-06-10T10:22:08-04:00June 10th, 2022|Articles|

Written by Yuning Wang, PhD June 3, 2022 Contents Background Four levels of protein structure How are protein structures studied? Background Structural information provides a great deal of understanding of how a protein works, which can allow us to elucidate molecular mechanisms underlying human diseases. Rapidly developing [...]

May 2022

What is HDX-MS Epitope Mapping?

2022-06-28T15:04:22-04:00May 15th, 2022|Articles|

Written by Yuning Wang, PhD May 13, 2022 Contents What is HDX-MS? HDX-MS Workflow Applications of HDX-MS HDX-MS Advantages HDX-MS Epitope Mapping of Antibodies HDX-MS Epitope Mapping at Rapid Novor What is HDX-MS? The origin of hydrogen-deuterium exchange (HDX) dates back to the 1950s, when protein scientist [...]