Rapid Novor Technical Note | REpAb Platform Series Authors: Chelsea Reitzel, Thierry Le Bihan Published: April 7, 2026 Contents Abstract Key Findings Background Decision Framework: Which Scenario Applies to You? Methods Results and Discussion Inter-Laboratory Titer Harmonization (Scenario C) Practical Workflow Summary Conclusion Abstract [...]
In this webinar, you will learn: How to select the appropriate bispecific antibody format based on your target and functional intent. How to apply the various manufacturing and protein engineering approaches to overcome bispecific complexity. How high-confidence monoclonal antibody sequencing enables reproducible bispecific design. Building Bispecific Antibodies with Confidence Bispecific [...]
In this webinar, you will learn: Explore how REpAb can sequence antibodies from the plasma of a naturally exposed human, identifying functional antibodies in circulation. Review study findings showing antibodies with broad inhibitory activity against diverse malaria variants, validated through structural and functional analysis. Learn how REpAb can be applied to study and [...]
In this webinar, you will learn: How to efficiently filter out non-specific binders early on to focus only on antibodies with true functional potential. Strategies to isolate highly specific anti-idiotype antibodies that avoid cross-reactivity with natural IgGs. The benefits of combining advanced enrichment techniques with proteomics to discover both blocking (type 1) [...]
In this webinar, you will learn: How mAb irreproducibility could unknowingly impact your research outcomes Proven strategies to mitigate reproducibility risks when using research reagents The role of antibody sequencing in ensuring reproducibility with mAbs Rapid, cost-effective sequence confirmation for routine applications The next frontier: polyclonal antibody sequencing and recombinant pAbs [...]
This paper is now published in Nature Communications! Le Bihan, T., Nunez de Villavicencio Diaz, T., Reitzel, C. et al. De novo protein sequencing of antibodies for identification of neutralizing antibodies in human plasma post SARS-CoV-2 vaccination. Nat Commun 15, 8790 (2024). https://doi.org/10.1038/s41467-024-53105-8 In this webinar, you will: Explore how using a [...]
Authors: Teresa Nunez de Villavicencio Diaz, Kyle Suttill, Chelsea Reitzel, Rosalin Dubois, Qixin Liu, Marko Jović, Dominic Narang, Thierry Le Bihan, Bin Ma Published: Nov 13, 2023, Revised: Nov 25, 2025 Abstract In this study, we demonstrate a novel approach for alpaca antibody discovery that bypasses traditional B [...]
Written by: Genya Gorshtein, MSc Published: November 25, 2022 Contents Introduction General PROTAC Structure and Function Antibody-Conjugated PROTACs Developing AbPROTACs with De Novo Antibody Sequencing and Proteomics Introduction Small-molecule drug development is aimed at inhibiting disease-promoting protein function through occupancy-driven protein inhibition. A major caveat of [...]
Written by: Genya Gorshtein, MSc Published: August 18, 2022 Contents Introduction How are Polyclonal Antibodies Produced? Applications of Polyclonal Antibodies Challenges of Polyclonal Antibodies De Novo Polyclonal Antibody Sequencing Introduction Polyclonal antibodies (pAbs) are a heterogeneous mix of antibodies derived from B cells in the [...]
Written by: Vanessa Yoon Calvelo, PhD Published: June 13, 2022 Contents What is CAR-T Cell Therapy? CAR Structure and Function CAR-T Cell Development Engineering Strategies for CAR-T Cells De Novo Protein Sequencing Applications in CAR-T Cell Development What is CAR-T Cell Therapy? The infusion of T cells [...]