December 2022

Cell Specific Protein Degradation with Antibody Conjugated PROTACs

2022-12-02T10:23:52-05:00December 2nd, 2022|Articles|

Written by Genya Gorshtein, MSc November 25, 2022 Contents Introduction General PROTAC Structure and Function Antibody-Conjugated PROTACs Developing AbPROTACs with De Novo Antibody Sequencing and Proteomics Introduction Small-molecule drug development is aimed at inhibiting disease-promoting protein function through occupancy-driven protein inhibition. A major caveat of this therapeutic [...]

October 2022

Characterizing Biomolecular Interactions with Surface Plasmon Resonance

2022-10-21T10:16:43-04:00October 21st, 2022|Articles|

Written by Vanessa Yoon Calvelo, PhD September 15, 2022 Contents Analyzing Biomolecular Interactions SPR Applications for Biomolecular Interactions SPR – A golden standard for biomolecular interaction analysis Analyzing Biomolecular Interactions Biological processes are driven by molecules that interact through specific molecular contacts, often to form a stable [...]

August 2022

What are Polyclonal Antibodies?

2022-11-17T13:24:32-05:00August 18th, 2022|Articles|

Written by Genya Gorshtein, MSc August 18, 2022 Contents Introduction How are Polyclonal Antibodies Produced? Applications of Polyclonal Antibodies Challenges of Polyclonal Antibodies De Novo Polyclonal Antibody Sequencing Introduction Polyclonal antibodies (pAbs) are a heterogeneous mix of antibodies derived from B cells in the adaptive immune system. [...]

Surface Plasmon Resonance Spectroscopy

2022-08-17T19:50:31-04:00August 16th, 2022|Articles|

Written by Vanessa Yoon Calvelo, PhD August 11, 2022 Contents What is Surface Plasmon Resonance Spectroscopy? How Does SPR Work? SPR Experimental Workflow SPR Sensorgram SPR Advantages Antibody-Antigen Binding Analysis with SPR SPR Antibody-Antigen Interaction Analysis at Rapid Novor What is Surface Plasmon Resonance Spectroscopy? Surface plasmon [...]

July 2022

Protein Characterization by HDX-MS

2022-10-27T11:20:06-04:00July 26th, 2022|Articles|

Written by Vanessa Yoon Calvelo, PhD July 21, 2022 Contents Mass spectrometry-based approaches for structural analysis of proteins HDX-MS Applications for ‘Difficult’ Proteins HDX-MS – A powerful analytical technique for protein characterization Mass spectrometry-based approaches for structural analysis of proteins Characterization of proteins and protein complexes is [...]

June 2022

What is Polyclonal Antibody Sequencing?

2022-11-24T16:16:27-05:00June 1st, 2022|Articles|

Written by Yuning Wang, PhD May 31, 2022 Contents Background What is Polyclonal Antibody Sequencing? Applications of Polyclonal Antibody Sequencing Advantages of Polyclonal Antibody Sequencing World’s First: De Novo Polyclonal Antibody Sequencing at Rapid Novor Background The native immune system produces polyclonal antibodies (pAb) by different B-cell [...]