December 2022

Technologies for Antibody Discovery and Generation

2023-03-03T14:54:14-05:00December 23rd, 2022|Articles|

Written by: Vanessa Yoon Calvelo, PhD Published: December 22, 2022 Contents The Great Debate in Antibody Discovery and Generation Traditional Antibody Discovery and Generation Technologies Emerging Antibody Discovery and Generation Technologies Antibody Discovery and Generation Technologies – Advantages and Disadvantages World’s First: Decoding Serum pAbs with Rapid Novor’s REpAb® Technology [...]

Cell Specific Protein Degradation with Antibody Conjugated PROTACs

2023-01-27T12:56:01-05:00December 2nd, 2022|Articles|

Written by: Genya Gorshtein, MSc Published: November 25, 2022 Contents Introduction General PROTAC Structure and Function Antibody-Conjugated PROTACs Developing AbPROTACs with De Novo Antibody Sequencing and Proteomics Introduction Small-molecule drug development is aimed at inhibiting disease-promoting protein function through occupancy-driven protein inhibition. A major caveat of [...]

October 2022

Characterizing Biomolecular Interactions with Surface Plasmon Resonance

2023-01-27T12:51:41-05:00October 21st, 2022|Articles|

Written by: Vanessa Yoon Calvelo, PhD Updated: January 18, 2023 (Published: September 15, 2022) Contents Analyzing Biomolecular Interactions is Fundamental to Understanding Biological Systems Analytical Techniques for Biomolecular Interactions SPR Applications for Biomolecular Interactions SPR – A golden standard for biomolecular interaction analysis Analyzing Biomolecular Interactions is [...]

August 2022

What are Polyclonal Antibodies?

2023-01-27T13:36:45-05:00August 18th, 2022|Articles|

Written by: Genya Gorshtein, MSc Published: August 18, 2022 Contents Introduction How are Polyclonal Antibodies Produced? Applications of Polyclonal Antibodies Challenges of Polyclonal Antibodies De Novo Polyclonal Antibody Sequencing Introduction Polyclonal antibodies (pAbs) are a heterogeneous mix of antibodies derived from B cells in the [...]

Surface Plasmon Resonance Spectroscopy

2023-02-21T20:57:14-05:00August 16th, 2022|Articles|

Written by: Vanessa Yoon Calvelo, PhD Updated: January 19, 2023 (Published: August 11, 2022) Contents What is Surface Plasmon Resonance Spectroscopy? What is SPR Used For? How Does SPR Work? SPR Experimental Workflow SPR Sensorgram SPR Advantages SPR Applications SPR Antibody-Antigen Interaction Analysis at Rapid Novor What is [...]

July 2022

Protein Characterization by HDX-MS

2023-01-27T12:53:07-05:00July 26th, 2022|Articles|

Written by: Vanessa Yoon Calvelo, PhD Published: July 21, 2022 Contents Mass spectrometry-based approaches for structural analysis of proteins HDX-MS Applications for ‘Difficult’ Proteins HDX-MS – A powerful analytical technique for protein characterization Mass spectrometry-based approaches for structural analysis of proteins Characterization of proteins and protein [...]

Adeno-Associated Virus Vectors for Gene Therapy Delivery

2023-02-21T20:54:33-05:00July 14th, 2022|Articles|

Written by: Vanessa Yoon Calvelo, PhD Published: July 11, 2022 Contents What is Gene Therapy? What are Adeno-Associated Viruses? Engineering of AAVs for Gene Therapy Engineering AAVs for Improved Transduction Engineering AAVs for Improved Immunogenicity De Novo Protein Sequencing Applications in AAV Characterization and Development What is Gene [...]

June 2022

What is Polyclonal Antibody Sequencing?

2022-11-24T16:16:27-05:00June 1st, 2022|Articles|

Written by Yuning Wang, PhD May 31, 2022 Contents Background What is Polyclonal Antibody Sequencing? Applications of Polyclonal Antibody Sequencing Advantages of Polyclonal Antibody Sequencing World’s First: De Novo Polyclonal Antibody Sequencing at Rapid Novor Background The native immune system produces polyclonal antibodies (pAb) by different B-cell [...]