Written By: Monica Mioduszewski Published: April 16, 2026 Contents Introduction How many animals are used in research? Which animals are used for testing? Why animal models remain in use Limitations of Animal Models New Approach Methodologies (NAMs): potential solutions to animal testing A persistent challenge: antibody generation Polyclonal Antibody Sequencing [...]
Rapid Novor Technical Note | REpAb Platform Series Authors: Chelsea Reitzel, Thierry Le Bihan Published: April 7, 2026 Contents Abstract Key Findings Background Decision Framework: Which Scenario Applies to You? Methods Results and Discussion Inter-Laboratory Titer Harmonization (Scenario C) Practical Workflow Summary Conclusion Abstract [...]
In this webinar, you will learn: How to select the appropriate bispecific antibody format based on your target and functional intent. How to apply the various manufacturing and protein engineering approaches to overcome bispecific complexity. How high-confidence monoclonal antibody sequencing enables reproducible bispecific design. Building Bispecific Antibodies with Confidence Bispecific [...]
In this webinar, you will learn: Explore how REpAb can sequence antibodies from the plasma of a naturally exposed human, identifying functional antibodies in circulation. Review study findings showing antibodies with broad inhibitory activity against diverse malaria variants, validated through structural and functional analysis. Learn how REpAb can be applied to study and [...]
In this webinar, you will learn: How to efficiently filter out non-specific binders early on to focus only on antibodies with true functional potential. Strategies to isolate highly specific anti-idiotype antibodies that avoid cross-reactivity with natural IgGs. The benefits of combining advanced enrichment techniques with proteomics to discover both blocking (type 1) [...]
Our client is a biotechnology company developing therapeutics that target cancer-specific carbohydrate antigens on the surface of tumour cells.
Our client is a biotechnology company developing therapeutics that target cancer-specific carbohydrate antigens on the surface of tumour cells.
Written by: Jenna Kerry, MSc Published: December 20, 2024 Contents What is Phage Display? How Does Phage Display Work? Phage Display Technology Advantages Phage Display Technology Limitations The Future of Phage Display Technology Overcoming Limitations of Phage Display Antibody Discovery What is Phage Display? Over [...]
Written by: Genya Gorshtein, MSc Published: December 12, 2024 Contents Introduction B Cells and Their Receptors Antibodies in Serum How Do You Discover Antibodies From Serum? Introduction While B cells play a crucial role in recognizing antigens and initiating immune responses, their differentiation into [...]
Written by: Genya Gorshtein, MSc Published: December 12, 2024 Contents Introduction BCR and Single B Cell Sequencing for Antibody Discovery Antibody Discovery through De Novo Sequencing of Serum Antibodies Proteogenomics: A Complimentary Approach Antibody Discovery With Rapid Novor Introduction B cell sequencing has long [...]
Written by: Jenna Kerry, MSc Published: November 6, 2024 Contents Why Humanize Antibodies? What is Antibody Humanization? Antibody Humanization Techniques Current Challenges of Antibody Humanization The Future of Human Antibody Therapeutics Fully Human Antibody Discovery / Human Antibody Discovery From Human Serum Why Humanize Antibodies? [...]
In this webinar, you will learn: How mAb irreproducibility could unknowingly impact your research outcomes Proven strategies to mitigate reproducibility risks when using research reagents The role of antibody sequencing in ensuring reproducibility with mAbs Rapid, cost-effective sequence confirmation for routine applications The next frontier: polyclonal antibody sequencing and recombinant pAbs [...]
Written by: Jenna Kerry, MSc Published: September 17, 2024 Contents Introduction Agonistic Antibody Mechanism of Action Agonistic Antibody Development Challenges Optimizing Agonistic Antibodies Agonistic Antibody Development Introduction In the last decade, immunotherapy has rapidly transformed treatments for cancer, autoimmune disorders, and infectious diseases. While the [...]
Principal Scientist in Polyclonal Antibody Sequencing Dr. Thierry Le Bihan joined Rapid Novor as a Principal Scientist in 2018, tasked with leading a multidisciplinary team to develop a polyclonal antibody sequencing platform. Thierry brought extensive proteomics and mass spectrometry expertise from his previous roles as Director of Proteomics at The Campbell Family Institute [...]
This paper is now published in Nature Communications! Le Bihan, T., Nunez de Villavicencio Diaz, T., Reitzel, C. et al. De novo protein sequencing of antibodies for identification of neutralizing antibodies in human plasma post SARS-CoV-2 vaccination. Nat Commun 15, 8790 (2024). https://doi.org/10.1038/s41467-024-53105-8 In this webinar, you will: Explore how using a [...]
Authors: Teresa Nunez de Villavicencio Diaz, Kyle Suttill, Chelsea Reitzel, Rosalin Dubois, Qixin Liu, Marko Jović, Dominic Narang, Thierry Le Bihan, Bin Ma Published: Nov 13, 2023, Revised: Nov 25, 2025 Abstract In this study, we demonstrate a novel approach for alpaca antibody discovery that bypasses traditional B [...]