In this webinar, you will learn: The challenges of developing biologics capable of crossing the blood-brain barrier (BBB) and emerging strategies for engineering BBB-penetrant therapeutics. Why multispecifics are an ideal vehicle for delivery of BBB therapeutics. How multispecifics targeting the BBB can be designed, validated and optimized for efficient transcytosis and TNF-α targeting [...]
Written by: Genya Gorshtein, MSc Published: January 6, 2023 Contents Introduction What is Affinity? What is Avidity? Measuring Affinity and Avidity: ELISA or SPR? Measuring Affinity And Avidity For Biological Applications Affinity and Avidity Analysis via SPR with Rapid Novor Introduction Kinetics of antibody-antigen interactions [...]
Written by: Genya Gorshtein, MSc Published: November 25, 2022 Contents Introduction General PROTAC Structure and Function Antibody-Conjugated PROTACs Developing AbPROTACs with De Novo Antibody Sequencing and Proteomics Introduction Small-molecule drug development is aimed at inhibiting disease-promoting protein function through occupancy-driven protein inhibition. A major caveat of [...]