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Why do Post-Translational Modifications Matter?
Written by: Vanessa Yoon Calvelo, PhD Updated: January 19, 2023 (Published: June 2, 2022) Contents What are post-translational modifications (PTMs)? Impact [...]
Protein Structure and How to Study It
Written by: Yuning Wang, PhD Updated: January 26, 2023 (Published: June 3, 2022) Contents Introduction The Four Levels of Protein [...]
Chimeric Antigen Receptors and T cells – CAR-T
Written by: Vanessa Yoon Calvelo, PhD Published: June 13, 2022 Contents What is CAR-T Cell Therapy? CAR Structure and Function CAR-T Cell [...]
Adeno-Associated Virus Vectors for Gene Therapy Delivery
Written by: Vanessa Yoon Calvelo, PhD Published: July 11, 2022 Contents What is Gene Therapy? What are Adeno-Associated Viruses? Engineering of [...]
Protein Characterization by HDX-MS
Characterization of proteins and protein complexes is a major keystone of structural biology. As our understanding of cellular processes continues to evolve from simple pathways to complicated networks, our need for advanced analytical methods is quite apparent. Mass spectrometry (MS)-based structural approaches can be used to study protein conformational changes and dynamics, protein motion/flexibility, ligand-protein binding, and protein-protein interfaces.
Moving Towards Biosimilar Drugs
Written by: Vanessa Yoon Calvelo, PhD Published: August 3, 2022 Contents What are Biosimilar Drugs? Why are Biosimilars Being Developed? Biosimilars [...]
Structure and Function of Antibodies
Written by Genya Gorshtein, MSc August 10, 2022 Contents General Structure of Antibodies Fab and Fc Fragments Hinge Region CDR and FR [...]
Surface Plasmon Resonance Spectroscopy
Written by: Vanessa Yoon Calvelo, PhD Updated: January 19, 2023 (Published: August 11, 2022) Contents What is Surface Plasmon Resonance Spectroscopy? [...]
What are Polyclonal Antibodies?
Written by: Genya Gorshtein, MSc Published: August 18, 2022 Contents Introduction How are Polyclonal Antibodies Produced? Applications of Polyclonal Antibodies [...]
What Generates Antibody Diversity?
Written by Genya Gorshtein, MSc Updated: January 27, 2023 (Published: August 31, 2022) Contents How is Antibody Diversity Generated? Which [...]
Characterizing Biomolecular Interactions with Surface Plasmon Resonance
Biological processes are driven by molecules that interact through specific molecular contacts, often to form a stable complex. These interactions are typically defined by the principles of thermodynamics as well as biomolecular structure and recognition. At the simplest level is the interaction between a target molecule with a specific binding site and a probing molecule that binds to that site, resulting in the bound complex.
The Hunt for Novel Therapeutics Through Antibody Engineering
Written by: Genya Gorshtein, MSc Published: November 1, 2022 Contents Introduction Approaches for Engineering Antibody Therapeutics Driving Antibody Engineering with Next [...]
Antibody Affinity and Avidity – The Strength of a Single Interaction Versus a Multivalent Interaction
Written by: Genya Gorshtein, MSc Published: January 6, 2023 Contents Introduction What is Affinity? What is Avidity? Measuring Affinity and [...]
Therapeutic Antibody Discovery: From Target to Candidate
Written by: Genya Gorshtein, MSc Published: February 17, 2023 Contents Introduction Target Discovery and Validation Antibody Discovery Characterization and Lead [...]
Navigating Intellectual Property Protection for Antibodies
In This Webinar, You Will Learn: Why IP is important in the development of antibody-based assets Patent application process and requirements How to [...]
Immunochemical Characterization of Therapeutic Antibodies
Written by: Vanessa Yoon Calvelo, PhD Published: April 14, 2023 Contents Introduction Immunochemical Properties of Therapeutic Antibodies Rapid Immunochemical Characterization of [...]
Secure Full Antibody and Target IP Protection with Next Generation Protein Sequencing
Written by: Genya Gorshtein, MSc Published: April 21, 2023 Contents Introduction Target Specification for First Generation Antibodies Patent Strategies for [...]
Functional Characterization of Therapeutic Antibodies
Written by: Vanessa Yoon Calvelo, PhD Published: April 24, 2023 Contents Introduction Functions of Therapeutic Antibodies Functional Assays for Therapeutic Antibodies [...]
Tackling Reproducibility in Life Sciences with Next Generation Protein Sequencing and Recombinant Expression
Written by: Genya Gorshtein, MSc Published: May 9, 2023 Contents Introduction Hybridoma Instability Leads to mAb Irreproducibility Batch-to-Batch Variation [...]
Antibody Drug Discovery and Development
Written by: Vanessa Yoon Calvelo, PhD Published: June 6, 2023 Contents The Drug Development Pathway: Overview and Challenges Early Discovery and [...]