Antibody Discovery Services2024-05-14T15:12:33-04:00

Antibody Discovery Services.

Mass spectrometry based in vivo antibody discovery platform. A flexible end-to-end workflow delivering developable, functional mAbs unseen by other modalities alone. Our antibody discovery service is mass spectrometry based, and powered by our unique REpAb technology.

Our Antibody Discovery Platform.

How It Works.

Our antibody discovery platform offers a complete suite of services to take you from immunization and de novo polyclonal antibody (pAb) sequencing, through to recombinant mAb expression, mAb characterization and ultimately lead selection.

Our unique technology allows antibody discovery by sequencing proteins directly from a complex mixture, using only mass spectrometry. We call this REpAb®. Leverage the entire natural immune response and begin the search for your lead molecule directly from functional native circulating antibodies.

showcase of antibody generation platform to obtain high affinity antibodies even for most challenging targets
Antigens Expression & Characterization Services � Peptide � Recombinant mAb expression in HEK or CHO cells � Protein � HDX-MS epitope and paratope mapping � Enzyme � Small Molecule

Species Agnostic Antibody Discovery Service

We can work with many species, including human antibodies and humanized animal. We are experienced in rabbit, alpaca, sheep, dog, chicken, human, and goat. Working with protein means you can test interaction with homologous targets in other model species early in your discovery campaign.

showcase of all species and isotypes disocvered with our antibody discovery service

Immunization

We have experience with tolerance breaking strategies such as using novel immunization, adjuvant and modification techniques to elicit an immune response. Additionally, a unique advantage of the REpAb® platform for tolerance busting is using different host species to raise antibodies against conserved proteins.

The REpAb® Advantage for Antibody Discovery.

What Are You Missing?

Depending on when and where you sample B-Cells for genomic sequencing, you may miss the best antibodies. We find unique antibodies not present in NGS data, which is crucial for therapeutic antibody discovery. If you’re not looking at the circulating antibody proteins, you’re missing out.

Broaden the Search.

Antibody discovery becomes easier when you:

  1. Search a bigger space and
  2. Improve the search strategy

Our REpAb® antibody discovery service considers the entire immune response (up to 1018 sequences) and leverages biology to select the best antibodies.

Quality vs Quantity of Hits.

We start with the most abundant, functional, circulating antibodies from the host organism because they offer:

  • Greater epitope diversity
  • A wide range of binding affinities
  • Reduced immunogenicity

REpAb® returns a few handfuls of the best leads and dozens of related sequences to fall back on.

Antibody Discovery Success Stories.

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“Rapid Novor was tasked with finding highly specific, high affinity antibodies against an important target- and they delivered powerful antibodies fit-for-purpose. Such antibodies are not easily obtained yet the Rapid Novor approach proved immediately successful, despite our time-constrained and stringent demands.”
Matt Pope, VP of Client Services, SISCAPA

Getting Started with our Antibody Discovery Services.

Requirements

Antigen or antigen information. We’ve worked with peptides, proteins, enzymes, and small molecules.

Price

We offer fee-for-service for all projects, and also offer milestone/royalty options for therapeutic discovery.

Deliverables

  • 5-85 mAb sequences with paired HC and LC
  • Additional CDR clusters sequences
  • Recombinantly expressed mAbs
  • SPR binding kinetics, screening and full profile
  • HDX-MS 3D epitope mapping report

“Our cutting edge antibody discovery service can select the very best antibodies out of millions of naturally evolved forms. REpAb® starts with a complex mixture of antibodies known to have affinity for your target. From there, we employ proprietary chemistry and various separation techniques, followed by dozens of LC-MS/MS runs and other mass spectrometry experiments. The resulting data is analyzed by our own de novo sequencing and assembly algorithms to produce full length IgG sequences.

Xiaobing Han, PhD
Xiaobing Han, PhDPrincipal Scientist, Ab Discovery

Talk to Our Scientists.

We Have Sequenced 9000+ Antibodies and We Are Eager to Help You.

Through next generation protein sequencing, Rapid Novor enables reliable discovery and development of novel reagents, diagnostics, and therapeutics. Thanks to our Next Generation Protein Sequencing and antibody discovery services, researchers have furthered thousands of projects, patented antibody therapeutics, and developed the first recombinant polyclonal antibody diagnostics.

Talk to Our Scientists.

We Have Sequenced 9000+ Antibodies and We Are Eager to Help You.

Through next generation protein sequencing, Rapid Novor enables timely and reliable discovery and development of novel reagents, diagnostics, and therapeutics. Thanks to our Next Generation Protein Sequencing and antibody discovery services, researchers have furthered thousands of projects, patented antibody therapeutics, and ran the first recombinant polyclonal antibody diagnostics

Talk to our scientists. We have sequenced over 9000+ antibodies and we are eager to help you.

Other Antibody Sequencing, Discovery and Characterization Services.

Antibody Sequencing & Discovery Services.

RapidSPR Analysis

Label-free evaluation of antibody-antigen binding using surface plasmon resonance on Biacore or Nicoya. Can be employed for detailed kinetic profiling, kinetics screening, or epitope binning.
Explore SPR Analysis

RapidHDX-MS

Mass spec based epitope mapping. Epitope mapping for identify the binding site of an antibody to its corresponding antigen with the highest confidence and resolution.
Explore HDX-MS Epitope Mapping

Antibody Characterization

LC-MS analysis for study of antibody glycosylation, disulfide bonds, post-translational modifications, sequence variants, intact mass and size.
Explore antibody characterization

MATCHmAb

Antibody verification by rapid peptide mapping. Antibody sequence confirmation and full detailed mapping for development purposes.
Explore Peptide Mapping

REmAb® mAb Sequencing

Monoclonal antibody sequencing from small antibodysamples, no need for hybridoma or DNA information. Full sequence in record time.
Explore Antibody Sequencing Services

REmAb® Protein Sequencing

Monoclonal antibody sequencing from small antibodysamples, no need for hybridoma or DNA information. Full sequence in record time.
Explore Antibody Sequencing Services