UniProt is a comprehensive, high-quality, and freely accessible resource of protein sequence and functional information. UniProt does not specifically focus on antibodies; as such, it only includes a representative set of germline antibody sequences and a limited number of non-germline antibody sequences.
The international ImMunoGeneTics information system (IMGT) is a global, high-quality integrated knowledge resource specializing in immunoglobulins (Ig), T cell Receptors (TcR), and Major Histocompatibility Complex (MHC) molecules of human and other vertebrates. IMGT comprises seven databases encompassing antibody sequence, genome, and structure. For example, IMGT/mAb-DB, the monoclonal antibody (mAb) database of IMGT, provides an expert resource on mAbs with clinical indications, and on fusion proteins for immune applications (FPIA).
abYsis is a web-based antibody research system that includes an integrated database of antibody sequence and structure data. abYsis can be used in three main ways:
- to search the database to find information about sequences (and structures) including detailed annotations, identification of unusual residues, post-translational modification sites, etc.,
- to analyze trends across sequences in the database, and
- to enter one’s own sequences for analysis.
Launched in 2020, the ABCD Database is a repository of sequenced antibodies, integrating curated information about the antibody and its antigen with cross-links to standardized databases of chemical and protein entities. Each antibody is assigned a unique ID number that can be used in academic publications to increase the reproducibility of experiments. Check out their tutorial to learn How to obtain an antibody sequence, Step-by-step.
Structural Antibody Database (SAbDab) is a database containing all the antibody structures available in the PDB, annotated and presented in a consistent fashion. The user can select structures, according to these attributes as well as structural properties such as complementarity determining region loop conformation and variable domain orientation.
Therapeutic Structural Antibody Database (Thera-SAbDab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the SAbDab with near-exact or exact variable domain sequence matches.
AAAAA is a tool for antibody structural analysis, modeling, and engineering. All sequences of variable domain germline and rearranged sequences in AAAAA are numbered in an identical way. AAAAA is quite useful for users to check antibody sequences for plausibility to find out about unusual residues, sequencing mistakes, frameshifts, insertions, and deletions.
OAS is a project to collect and annotate immune repertoires for use in large-scale analysis. It currently contains over one billion sequences, from more than 79 different studies. These repertoires cover diverse immune states, organisms (primarily human and mouse), and individuals. OAS now contains both unpaired and paired antibody sequences.
cAb-Rep is a database of curated antibody repertoires. It currently includes 306 B cell repertoires collected from 121 human individuals, including healthy, vaccinated, and autoimmune disease donors. The database has a total of 267.9 and 72.9 million curated full-length V(D)J heavy and light chain transcripts respectively, which were generated using Illumina sequencing technology in previous studies.