About Yuning Wang

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So far Yuning Wang has created 22 blog entries.

June 2022

Protein Structure and How to Study it

2022-06-10T10:22:08-04:00June 10th, 2022|Articles|

Written by Yuning Wang, PhD June 3, 2022 Contents Background Four levels of protein structure How are protein structures studied? Background Structural information provides a great deal of understanding of how a protein works, which can allow us to elucidate molecular mechanisms underlying human diseases. Rapidly developing [...]

What is Polyclonal Antibody Sequencing?

2022-06-01T10:46:05-04:00June 1st, 2022|Articles|

Written by Yuning Wang, PhD May 31, 2022 Contents Background What is Polyclonal Antibody Sequencing? Applications of Polyclonal Antibody Sequencing Advantages of Polyclonal Antibody Sequencing World’s First: De Novo Polyclonal Antibody Sequencing at Rapid Novor Background The native immune system produces polyclonal antibodies (pAb) by different B-cell [...]

May 2022

What is HDX-MS Epitope Mapping?

2022-06-28T15:04:22-04:00May 15th, 2022|Articles|

Written by Yuning Wang, PhD May 13, 2022 Contents What is HDX-MS? HDX-MS Workflow Applications of HDX-MS HDX-MS Advantages HDX-MS Epitope Mapping of Antibodies HDX-MS Epitope Mapping at Rapid Novor What is HDX-MS? The origin of hydrogen-deuterium exchange (HDX) dates back to the 1950s, when protein scientist [...]

April 2022

Identifying CDRs by Antibody Sequencing

2022-04-13T12:41:06-04:00April 1st, 2022|Articles|

Contents What are CDRs? Antibody CDRs De Novo Protein Sequencing as a Tool for Identifying CDRs sequences Applying De Novo Protein Sequencing to Identify CDRs Sequences Annotation schemes for identifying CDRs by Sequence Rapid Novor can Help with Identifying CDRs by Sequence What are CDRs? The acronym “CDR” stands [...]

March 2022

February 2022

Camelid Antibodies and Nanobodies

2022-04-13T12:24:47-04:00February 4th, 2022|Articles|

Written by Yuning Wang, PhD Contents Discovery of camelid antibodies What are camelid antibodies? Structure of camelid antibodies and nanobodies Applications of nanobodies How are nanobodies developed? References Discovery of camelid antibodies Three decades ago, the discovery1 of a peculiar type of antibody [...]

November 2021

October 2021

What is Peptide Mapping?

2022-04-25T20:15:08-04:00October 28th, 2021|Articles|

Peptide mapping is a widely used analytical technique to verify the primary structure (amino acid sequence) and characterize the chemical modifications of a protein. It analyzes peptides generated from the digestion of an isolated protein, or a protein mixture

Ushering the New Era in Anti-Drug Antibody Assays with Next Generation Protein Sequencing

2022-04-18T20:15:18-04:00October 15th, 2021|Whitepapers|

Anti-drug antibody (ADA) assays are critical to assess the clinical efficacy and safety of a biological drug and rely on control reagents that mimic the ADA response to the biological drug being tested. These positive controls typically consist of animal-derived pooled polyclonal antibodies or human monoclonal antibody reference panels against the target protein drug.

July 2021

Isoleucine and Leucine

2022-03-23T10:16:31-04:00July 7th, 2021|Articles|

Because they share the same mass, isoleucine and leucine are known as isobaric amino acids. Conventional mass spectrometry-based proteomics cannot be easily used to distinguish between isoleucine and leucine.

June 2021

Bispecific Therapeutics Explained

2022-04-25T18:18:31-04:00June 28th, 2021|Articles|

Bispecific therapeutics are monoclonal antibodies that carry a specific antigen-binding capability on each arm. Bispecifics are thus capable of having two specificities that can either double the binding affinity of the antibody toward the same antigen (increased avidity), or can now bind to two targets. Bispecifics are most often described as two types: trispecifics and bispecific T-cell engaged antibodies (BiTE).

Types of Antibodies

2021-11-18T11:31:31-05:00June 25th, 2021|Articles|

Written by María Gerpe, PhD June 25, 2021 Introduction Antibodies or immunoglobulins (Ig) are Y-shaped glycoproteins produced by the adaptive immune system in response to antigens - substances or molecules the immune system deems as foreign. Antibodies bind to an antigen and either directly neutralize it, or activate other parts of [...]

March 2021

The Underlying Cause of Medical Diagnostic Invalidation

2021-11-23T09:41:41-05:00March 23rd, 2021|Whitepapers|

In-vitro diagnostics (IVDs) are one of the most commonly used tools to diagnose conditions and guide treatment decisions and are often considered the “silent champion” of healthcare. They work by detecting the absence or presence of particular markers or by measuring the concentration of analytes or specific substances.

February 2017

Antibody Protein Sequence Analysis Using Mass Spectrometry

2022-04-25T18:11:31-04:00February 3rd, 2017|Articles|

One of the most important pieces of information researchers need to know during early stage antibody drug research and development is the sequence information of the antibody protein. With the advancement of mass spectrometry instrumentation and technologies, it is helpful, and sometimes critical, to conduct sequence analysis using mass spectrometry experiments.