About Jessica Barber

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So far Jessica Barber has created 4 blog entries.

Study: De Novo Protein Sequencing Vs. DNA Sequencing

A Large-Scale Comparison of MS-based Antibody De Novo Protein Sequencing and Targeted DNA Sequencing Introduction The DNA sequences of antibodies are highly diverse due to the V-(D)-J recombination and hypersomatic mutations. As such, a new antibody of interest is unlikely to appear in any existing sequence database. Consequently, the database search approach commonly used in [...]

2019-06-19T10:56:43-04:00June 7th, 2019|Blog, Research|0 Comments

Prevalence of Secondary Light Chains

Introduction Monoclonal antibodies (mAbs) are widely used in research, diagnosis, and pharmaceutical purposes. Lately, the relatively lower quality of the research-purpose mAbs is a point of concern within the research community¹,². The problems include the lack of validation and low reproducibility. As most of the validation is done by immunoassay, the extent of protein contamination, [...]

2019-02-05T16:01:59-04:00February 5th, 2019|Blog, Research|0 Comments